2024
- Establishment of a spheroid-based cell culture system for exposure studies
2023
- Determining the number of skin operations saved by using confocal laser scanning microscopy
- Determination of the colloidal and conformational stability of therapeutic antibodies based on time-dependent and time-independent stability parameters using various bioanalytical methods
- Conceptualisation and development of two test apparatuses for testing medical device packaging
- Programming of an MEG-based neurofeedback paradigm of peripheral physiological signals using the example of respiratory function
- Reverse fractional kill time studies using enzymatic indicators for the decontamination cycle of isolators with vaporised hydrogen peroxide
- Development and construction of a model for optimal leg positioning in a female patient for transurethral bladder catheterization
- Demonstration of the Scientific Validity and Evaluation of the Performance Evaluation Parameter Precision for CyFlow™ Monoclonal Antibodies According to the EU in vitro Diagnostic Medical Device Regulation 2017/746 (IVDR)
- Planning and development of simulation software for a foot switch to automate verification tests
- Development of a serological on-farm rapid test for the detection of Mycoplasma hyopneumoniae infection
- eNVH investigations of a laboratory centrifuge using frequency analysis and experimental modal analyses to develop optimisations
2022
- Functional analysis of radiation-induced lncRNAs lincBRCA1-3_1, lincBRCA1-3_6 and lincBRCA1-3_15 in normal human breast eptihel cell line MCF10A
- Comparison of encephalographic methods (MEG, EEG) and source analyses of visually evoked responses
- Investigation of the influence of separate NO dosing in a membrane lung on blood in the ECMO circuit
- Construction of an adhesively fixed ultrasound transducer holder for independent performance of exercises for the deep back muscles
2021
- Calcium isotope analysis of kidney stones and associated blood and urine using MC-ICP-MS
- Robot-assisted analysis of glenohumeral stability under the influence of rotator cuff ruptures
- Analysis of Cannabidiol induced cell death in tumor cells, human and mice fibroblasts and rat cardiomyoblasts
- Measurment of Glenoid Concavity by Computed Tomography and Magentic Resonance Imaging
- Investigation of systematic deviations in absorption measurements of a flashlamp-based reader
- Design, layout and modelling of a prototype for a floor-based robot for high-precision patient positioning in radiotherapy
- Identification of copy number variations (CNV) in cardiac disease genes using next generation sequencing (NGS) and secondary validation by quantitative PCR or MLPA
- Particulate formulation of a clinical monoclonal antibody with chitosan as a carrier material for the therapy of multiple sclerosis
- Prototyping a ROS based 3-axis Traversing System with onboard temperature logging
2020
- Creation of phantoms as model system suitable for near infrared (NIR) laparoscopy
- Development of a fluorescence-based biosensor for the detection of a signal lipid and its dynamics
- Phase transfer of hydrophobic quantum dots into aqueous solution for use in cell culture
- Immunological detection of sport-induced expression of the myokines DOC2B and KLC1 in type 2 diabetics
- Characterization of a Microfluidic System for Co-Localization of Cell-Laden Hydrogel Matrices Enabling Cellular Interaction Studies Between Immune Cells and Tumor Cells
2019
- Synthesis of superparamagnetic iron oxide nanoparticles in a polymethyl methacrylate matrix
- Development of a POC prototype for the investigation of drainage fluid during laparoscopic operations
- Retrospective fusion of PET and MRT: Comparison of the visibility of liver lesions in positron emission tomography and diffusion-weighted and contrast medium-assisted magnetic resonance tomography
- Pulsatile Characterization of the CorWave Left Ventricular Device in static and physiological environment
- Novel digitomotography variables in quantitative motor tests (Q-Motor) in Huntington's Disease, validated against the TRACK-HD data set
- Evaluation of measurement systems for the performance evaluation of steam sterilization and cleaning disinfection processes
- Characterization of heat shock proteins and their influence on the organization of the plasma membrane in Saccharomyces cerevisiae
2018
- Transfer of the CRISPR / Cas9 method to the automated cell culture microscopes and the associated image processing and control software of SYNENTEC GmbH.
- Tracking of human neutrophil granolucytes after myocardial infacation using 19F MRT
- Establishment of in vitro toxicity tests for low density microplastic particles to determine cell viability and cell death of adherent cells
- Determination of a correlation between biological and enzymatic indicators in the biodecontamination of closed barrier systems with hydrogen peroxide
- Investigation of an antimicrobial polymer varnish for use in ventilation systems with five human pathogens on the basis of Japanese Industrial Standard Z 2801
2017
- Mechanisms of ion transport and segregation of charge during transcranial direct current stimulation (tDCS): a multichannel magnetoencephalographic study
- Adaption of a manual Toxoplasma gondii IgG ELISA to a fully automated analyzer
- Optimization of a measurement method for determination of the diffuse performance of low-flux dialysis membranes (polyether sulfone)
- Force measurements in developing Zebrafish using hydrogel based stress sensors
- Enzymatic hydroxylation of steroids
- Identification and characterization of tumor inhibiting and oncogenic micro-RNAs of HCC using in-vitro and in-vivo techniques
- The relevance of ubiquitin-modified lysine residues in the viral polymerase of the influenza-A-virus on RNA sythesis
- Optimization, scale-up and economic analysis of the production of β-aspartyl-L-ornithine and β-L-aspartyl-L-citrulline by selective hydrolysis of β-L-aspartyl-L-arginine
- Development of a Post-Market Surveillance Program for the Root Canal Instruments Product Family as Part of Quality Management
2016
- Improvement of the sensitivity of a saliva-based THC immunoassay
- Genotoxic effects in in-vitro nanotoxicology: Application of the alkaline comet assay on fibroblasts after co-culture with alveolar macrophages
- Factors influencing the effectiveness of fungicidal agents in mold remediation
- Effect of culture medium and transduction on endothelial phenotype
- Depletion of SDS/SDC in decellularized porcine heart valves by means of protic solvents
- Microbiological study about the suitability of mineral preservatives for pan and coating conservation in comparison to conventional preservation methods
2015
- Evaluation of an automated synthetic micro-dosing method for the reinforcement of polycarbonate-urethane heart valves
- Magnetoencephalographic examination of the charge distribution induced by directed DC stimulation (tDCS) on a physiological spherical model
- Safety notifications from clinical trials with medical devices: Comparative analysis of European reporting forms witg regard to the use of drug databases based on the ICH E2B data sets
- Selection, dimensioning and qualification of a tissue cutting method for medical implants
- Use of capnovolumetry as a supplementary diagnostic method for pulmonary function testing
- Development of a strategic concept based on an environmental and company analysis of the hospital communication sector
- New development of a fatigue test system for examining standard and in vivo tests on ceramic hip joint components
- Development of a physical method for the determination of the tightness and controlled opening of an original closure of a medical device
- Investigation of the relationship between different methods for the determination of day drowsiness or vigilance
- MOF-based nanoparticles as drug delivery systems
2014
- Development of a highly precise microprocessor-controlled thermostat for laser and light emitting diodes in miniaturized analysers
- Conjugation of spin labelled proteins with fluorescent quantum dots
- Development of a user interface using Matlab for the automated detection of hearing responses in a "Neural Response Imaging" measurement
- Comparison of the electrical and magnetic transcranial evoked potentials in patients with compression of spinal motor pathways
- Physical characterisation of nanoparticles
- Evaluation of methods for the detection and correction of head movements during the measurements in the entire head neuro magnetometer system (MEG)
- Fundamental considerations on the design and the mode of operation of valve structures made of thin films
2013
- Development of a signal processing algorithm for energy efficient Laser Doppler perfusion monitoring
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Optimisation of the biotinylation of allergens for the use in a BDLiquid System
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Quantitative detection of elements on the skin in cases of current-induced death in bathtubs
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Recursive Pitch-Matching
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Design of a procedure for the determination of the minimum shelf life of medical devices during their development, taking into account the economic factors and the use of these results through product examples
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Development of a marketing strategy to communicate the changing level basis to in vitro diagnostics manufacturers and within the notified office based on an analysis of the effects of the new regulations (degree programme industrial engineering)
- Autodisplay of plant cytochrome P450 monooxygenases and characterisation of the obtained whole cell biocatalysts
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Development of a surgial table for ophthalmology
- Development of a compact measurement device for the switchSENSE technolgy
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Analysis of process related solution components in protein containing formulations
- Development of a three-dimensonal cellular assay for use in high-content screening
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Development of a method for the enrichment of circulating tumor cells from whole blood and their subsequent isolation on biocompatible hydrogel matrices
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Optimisation and validation of a STR-multiplex analysis for pigeons
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Interactions of procaryotic and eucaryotic cells with nanostructured titanium surfaces produced by the glancing angle deposition technique
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Characterisation of DNA isolation methods for the follow up use of real-time PCR in a point-of-care system
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Automated growth process monitoring of yeast cells in bioreactors
2012
- Cell fate of hMSCs in a bottom-up approach for complex 3D engineered tissues
- Epithelial-mesenchymal interactions during branching morphogenesis in a three-dimensional lung cell culture model
- Recombinant expression of bacillolysin in Bacillus subtilis
- Establishment of the analysis of pioglitazone and the validation of the "dried blood spot (DBS)" method in Callithrix jacchus / Macaca fascicularis
2011
- Detection of gene rearrangements using fluorescent in-situ hybridisation (FISH) in radiation-associated mammary carcinomas
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The left heart bypass - Use of extracorporeal circulation during operations on the thoracic aorta
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Development and validation of a partially automated method for water disinfection in hypothermia devices by means of ozone
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New development and evaluation of a γH2AX-foci-assay by means of the automated evaluation of the AKLIDES® technology and the assembly and design of the corresponding kit
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Development of segmented tube heating elements for the control of optimized breathing gas temperature
- Application development for real-time rapid PCR and comparison of manual and automatic liquid handling
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Development and characterisation of a model system for enzymatic debridement
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Influence of nanoparticles (dentritic polyglycerol sulfates) and various microfleece fibretopologies on the expression profile and differentiation of cartilage cells with regard to arthrosis therapie
2010
- Laboratory quality management system for a urology specialist practice
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Intensified first-sample inspection of the Omnitest 3 blood glucose meter with special regard to its suitability for use
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Investigation of the feasibility of the impedance measurements with microbial united cell structures
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Establishment of a data processing software using MS Access for trace analysis in the field of forensic molecular genetics
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Development of an epidural catheter for short term epidural anaesthesia
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Transfer of mRNA in respiratory epithelial cells by means of magnetofection
- Characterisation of HA-based bone replacement material produced by powder injection moulding
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Qualitative comparison of the minimal extra corporeal circulation system ROCsafeRX from the company Terumo with two conventional extra corporeal circulation systems, considering specific peri- and postoperative parameters during bypass operations
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Investigations of novel digital holographic microscopy methods for the analysis of living cells
2009
- Cloning of an allelic ladder for a forensic mtDNA SNP detection method
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Innovative sampling device for tissue samples of the cervix
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Investigation of thermal markers
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Determination of the atrial and ventricular mechanical activity with an implantable sensor
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Production of 3-D photonic crystals via self-organisation
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Material tests on medical implants made of nickel-titanium
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Determination of a correlation between adhesive strength / pH value / release of active substance of a moist self-adhesive film and its chemical compounding
- Process validation of a titanium injection moulding method based on DIN EN ISO 13485:2003
- Conception and production of a microfluidic component for sorting droplets
- Strength analysis of osteosynthesis plates in veterinary medicine
- Magnetic nanoparticles: Feasibility for biomedical applications
- Prototype development of a point-of-care system for molecular biology diagnostic of oral infections
- Microrarray-based DNA polymerase reactions as highly sensitive detection and genotyping tests